Synaptotagmin-13 (SYT13)

About Synaptotagmin-13

Synaptotagmin-13 (SYT13) is a protein from Homo sapiens identified by UniProt accession Q7L8C5, 426 residues long. MolForge cross-references it against 0 known binders and 92 disease associations.

Target properties

Protein name	Synaptotagmin-13
UniProt accession	Q7L8C5
Gene	SYT13
Organism	Homo sapiens
Length	426 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (92)

Diseases linked to this target (Open Targets).

body height · score 0.37
neurodegenerative disease · score 0.37
systolic blood pressure · score 0.32
body mass index · score 0.32
schizophrenia · score 0.29
pulse pressure measurement · score 0.27
Thyrotoxicosis · score 0.25
type 2 diabetes mellitus · score 0.24
age at menarche · score 0.24
intraocular pressure measurement · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q7L8C5-F1	alphafold	PREDICTED	68.92	—

Amino-acid sequence (426 residues)

MVLSVPVIAL GATLGTATSI LALCGVTCLC RHMHPKKGLL PRDQDPDLEK AKPSLLGSAQ QFNVKKSTEP VQPRALLKFP DIYGPRPAVT APEVINYADY SLRSTEEPTA PASPQPPNDS RLKRQVTEEL FILPQNGVVE DVCVMETWNP EKAASWNQAP KLHYCLDYDC QKAELFVTRL EAVTSNHDGG CDCYVQGSVA NRTGSVEAQT ALKKRQLHTT WEEGLVLPLA EEELPTATLT LTLRTCDRFS RHSVAGELRL GLDGTSVPLG AAQWGELKTS AKEPSAGAGE VLLSISYLPA ANRLLVVLIK AKNLHSNQSK ELLGKDVSVK VTLKHQARKL KKKQTKRAKH KINPVWNEMI MFELPDDLLQ ASSVELEVLG QDDSGQSCAL GHCSLGLHTS GSERSHWEEM LKNPRRQIAM WHQLHL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards