PHD finger-like domain-containing protein 5A (PHF5A)

About PHD finger-like domain-containing protein 5A

PHD finger-like domain-containing protein 5A (PHF5A) is a protein from Homo sapiens identified by UniProt accession Q7RTV0, 110 residues long. MolForge cross-references it against 0 known binders and 144 disease associations.

Target properties

Protein name	PHD finger-like domain-containing protein 5A
UniProt accession	Q7RTV0
Gene	PHF5A
Organism	Homo sapiens
Length	110 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (144)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.35
neoplasm · score 0.10
hepatocellular carcinoma · score 0.09
cancer · score 0.09
self reported educational attainment · score 0.09
lung adenocarcinoma · score 0.08
head and neck squamous cell carcinoma · score 0.08
gonorrhea · score 0.07
esophageal squamous cell carcinoma · score 0.07
refractive error · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q7RTV0-F1	alphafold	PREDICTED	89.88	—

Amino-acid sequence (110 residues)

MAKHHPDLIF CRKQAGVAIG RLCEKCDGKC VICDSYVRPC TLVRICDECN YGSYQGRCVI CGGPGVSDAY YCKECTIQEK DRDGCPKIVN LGSSKTDLFY ERKKYGFKKR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards