About Proton-coupled amino acid transporter 1
Proton-coupled amino acid transporter 1 (SLC36A1) is a protein
from Homo sapiens identified by UniProt accession
Q7Z2H8, 476 residues long.
MolForge cross-references it against 0 known binders and
43 disease associations.
Target properties
| Protein name | Proton-coupled amino acid transporter 1 |
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| UniProt accession | Q7Z2H8 |
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| Gene | SLC36A1 |
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| Organism | Homo sapiens |
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| Length | 476 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (43)
Diseases linked to this target (Open Targets).
- basophil count · score 0.43
- neurodegenerative disease · score 0.42
- basophil percentage of leukocytes · score 0.40
- Red cell distribution width · score 0.39
- Alzheimer disease · score 0.37
- Parkinson disease · score 0.37
- multiple sclerosis · score 0.37
- lysosomal storage disease · score 0.37
- blood protein measurement · score 0.30
- basophil percentage of granulocytes · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7Z2H8-F1 | alphafold | PREDICTED | 84.91 | — |
Amino-acid sequence (476 residues)
MSTQRLRNED YHDYSSTDVS PEESPSEGLN NLSSPGSYQR FGQSNSTTWF QTLIHLLKGN IGTGLLGLPL AVKNAGIVMG PISLLIIGIV AVHCMGILVK CAHHFCRRLN KSFVDYGDTV MYGLESSPCS WLRNHAHWGR RVVDFFLIVT QLGFCCVYFV FLADNFKQVI EAANGTTNNC HNNETVILTP TMDSRLYMLS FLPFLVLLVF IRNLRALSIF SLLANITMLV SLVMIYQFIV QRIPDPSHLP LVAPWKTYPL FFGTAIFSFE GIGMVLPLEN KMKDPRKFPL ILYLGMVIVT ILYISLGCLG YLQFGANIQG SITLNLPNCW LYQSVKLLYS IGIFFTYALQ FYVPAEIIIP FFVSRAPEHC ELVVDLFVRT VLVCLTCILA ILIPRLDLVI SLVGSVSSSA LALIIPPLLE VTTFYSEGMS PLTIFKDALI SILGFVGFVV GTYEALYELI QPSNAPIFIN STCAFI
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