About tRNA (guanine(27)-N(2))-dimethyltransferase
tRNA (guanine(27)-N(2))-dimethyltransferase (TRMT1L) is a protein
from Homo sapiens identified by UniProt accession
Q7Z2T5, 733 residues long.
MolForge cross-references it against 0 known binders and
44 disease associations.
Target properties
| Protein name | tRNA (guanine(27)-N(2))-dimethyltransferase |
|---|
| UniProt accession | Q7Z2T5 |
|---|
| Gene | TRMT1L |
|---|
| Organism | Homo sapiens |
|---|
| Length | 733 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (44)
Diseases linked to this target (Open Targets).
- grip strength measurement · score 0.30
- sex hormone-binding globulin measurement · score 0.26
- cigarettes per day measurement · score 0.25
- platelet count · score 0.23
- leukocyte count · score 0.20
- gait measurement · score 0.20
- basophil count · score 0.20
- platelet crit · score 0.20
- urate measurement · score 0.17
- uric acid measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7Z2T5-F1 | alphafold | PREDICTED | 72.69 | — |
Amino-acid sequence (733 residues)
MENMAEEELL PLEKEEVEVA QVQVPTPARD SAGVPAPAPD SALDSAPTPA SAPAPAPALA QAPALSPSLA SAPEEAKSKR HISIQRQLAD LENLAFVTDG NFDSASSLNS DNLDAGNRQA CPLCPKEKFR ACNSHKLRRH LQNLHWKVSV EFEGYRMCIC HLPCRPVKPN IIGEQITSKM GAHYHCIICS ATITRRTDML GHVRRHMNKG ETKSSYIAAS TAKPPKEILK EADTDVQVCP NYSIPQKTDS YFNPKMKLNR QLIFCTLAAL AEERKPLECL DAFGATGIMG LQWAKHLGNA VKVTINDLNE NSVTLIQENC HLNKLKVVVD SKEKEKSDDI LEEGEKNLGN IKVTKMDANV LMHLRSFDFI HLDPFGTSVN YLDSAFRNIR NLGIVSVTST DISSLYAKAQ HVARRHYGCN IVRTEYYKEL AARIVVAAVA RAAARCNKGI EVLFAVALEH FVLVVVRVLR GPTSADETAK KIQYLIHCQW CEERIFQKDG NMVEENPYRQ LPCNCHGSMP GKTAIELGPL WSSSLFNTGF LKRMLFESLH HGLDDIQTLI KTLIFESECT PQSQFSIHAS SNVNKQEENG VFIKTTDDTT TDNYIAQGKR KSNEMITNLG KKQKTDVSTE HPPFYYNIHR HSIKGMNMPK LKKFLCYLSQ AGFRVSRTHF DPMGVRTDAP LMQFKSILLK YSTPTYTGGQ SESHVQSASE DTVTERVEMS VNDKAEASGC RRW
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