About Lysosomal cholesterol signaling protein
Lysosomal cholesterol signaling protein (GPR155) is a protein
from Homo sapiens identified by UniProt accession
Q7Z3F1, 870 residues long.
MolForge cross-references it against 0 known binders and
44 disease associations.
Target properties
| Protein name | Lysosomal cholesterol signaling protein |
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| UniProt accession | Q7Z3F1 |
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| Gene | GPR155 |
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| Organism | Homo sapiens |
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| Length | 870 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (44)
Diseases linked to this target (Open Targets).
- HbA1c measurement · score 0.34
- hemoglobin A1 measurement · score 0.28
- mean platelet volume · score 0.15
- platelet component distribution width · score 0.11
- hepatocellular carcinoma · score 0.07
- adolescent idiopathic scoliosis · score 0.06
- gonorrhea · score 0.05
- kidney disease · score 0.04
- familial papillary thyroid carcinoma with renal papillary neoplasia · score 0.03
- renal dysplasia · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7Z3F1-F1 | alphafold | PREDICTED | 73.23 | — |
Amino-acid sequence (870 residues)
MNSNLPAENL TIAVNMTKTL PTAVTHGFNS TNDPPSMSIT RLFPALLECF GIVLCGYIAG RANVITSTQA KGLGNFVSRF ALPALLFKNM VVLNFSNVDW SFLYSILIAK ASVFFIVCVL TLLVASPDSR FSKAGLFPIF ATQSNDFALG YPIVEALYQT TYPEYLQYIY LVAPISLMML NPIGFIFCEI QKWKDTQNAS QNKIKIVGLG LLRVLQNPIV FMVFIGIAFN FILDRKVPVY VENFLDGLGN SFSGSALFYL GLTMVGKIKR LKKSAFVVLI LLITAKLLVL PLLCREMVEL LDKGDSVVNH TSLSNYAFLY GVFPVAPGVA IFATQFNMEV EIITSGMVIS TFVSAPIMYV SAWLLTFPTM DPKPLAYAIQ NVSFDISIVS LISLIWSLAI LLLSKKYKQL PHMLTTNLLI AQSIVCAGMM IWNFVKEKNF VGQILVFVLL YSSLYSTYLW TGLLAISLFL LKKRERVQIP VGIIIISGWG IPALLVGVLL ITGKHNGDSI DSAFFYGKEQ MITTAVTLFC SILIAGISLM CMNQTAQAGS YEGFDQSQSH KVVEPGNTAF EESPAPVNEP ELFTSSIPET SCCSCSMGNG ELHCPSIEPI ANTSTSEPVI PSFEKNNHCV SRCNSQSCIL AQEEEQYLQS GDQQLTRHVL LCLLLIIGLF ANLSSCLWWL FNQEPGRLYV ELQFFCAVFN FGQGFISFGI FGLDKHLIIL PFKRRLEFLW NNKDTAENRD SPVSEEIKMT CQQFIHYHRD LCIRNIVKER RCGAKTSAGT FCGCDLVSWL IEVGLASDRG EAVIYGDRLV QGGVIQHITN EYEFRDEYLF YRFLQKSPEQ SPPAINANTL QQERYKEIEH SSPPSHSPKT
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