About Transmembrane protease serine 9
Transmembrane protease serine 9 (TMPRSS9) is a protein
from Homo sapiens identified by UniProt accession
Q7Z410, 1059 residues long.
MolForge cross-references it against 0 known binders and
18 disease associations.
Target properties
| Protein name | Transmembrane protease serine 9 |
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| UniProt accession | Q7Z410 |
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| Gene | TMPRSS9 |
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| Organism | Homo sapiens |
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| Length | 1059 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (18)
Diseases linked to this target (Open Targets).
- age-related hearing impairment · score 0.32
- Global developmental delay · score 0.30
- diet measurement · score 0.20
- hearing loss · score 0.20
- diffuse plaque measurement · score 0.17
- mathematical ability · score 0.04
- platelet count · score 0.04
- childhood disintegrative disorder · score 0.04
- severe early-onset obesity-insulin resistance syndrome due to SH2B1 deficiency · score 0.03
- neutrophil percentage of leukocytes · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7Z410-F1 | alphafold | PREDICTED | 74.40 | — |
Amino-acid sequence (1059 residues)
MEPTVADVHL VPRTTKEVPA LDAACCRAAS IGVVATSLVV LTLGVLLAFL STQGFHVDHT AELRGIRWTS SLRRETSDYH RTLTPTLEAL LHFLLRPLQT LSLGLEEELL QRGIRARLRE HGISLAAYGT IVSAELTGRH KGPLAERDFK SGRCPGNSFS CGNSQCVTKV NPECDDQEDC SDGSDEAHCE CGLQPAWRMA GRIVGGMEAS PGEFPWQASL RENKEHFCGA AIINARWLVS AAHCFNEFQD PTKWVAYVGA TYLSGSEAST VRAQVVQIVK HPLYNADTAD FDVAVLELTS PLPFGRHIQP VCLPAATHIF PPSKKCLISG WGYLKEDFLV KPEVLQKATV ELLDQALCAS LYGHSLTDRM VCAGYLDGKV DSCQGDSGGP LVCEEPSGRF FLAGIVSWGI GCAEARRPGV YARVTRLRDW ILEATTKASM PLAPTMAPAP AAPSTAWPTS PESPVVSTPT KSMQALSTVP LDWVTVPKLQ ECGARPAMEK PTRVVGGFGA ASGEVPWQVS LKEGSRHFCG ATVVGDRWLL SAAHCFNHTK VEQVRAHLGT ASLLGLGGSP VKIGLRRVVL HPLYNPGILD FDLAVLELAS PLAFNKYIQP VCLPLAIQKF PVGRKCMISG WGNTQEGNAT KPELLQKASV GIIDQKTCSV LYNFSLTDRM ICAGFLEGKV DSCQGDSGGP LACEEAPGVF YLAGIVSWGI GCAQVKKPGV YTRITRLKGW ILEIMSSQPL PMSPPSTTRM LATTSPRTTA GLTVPGATPS RPTPGAASRV TGQPANSTLS AVSTTARGQT PFPDAPEATT HTQLPDCGLA PAALTRIVGG SAAGRGEWPW QVSLWLRRRE HRCGAVLVAE RWLLSAAHCF DVYGDPKQWA AFLGTPFLSG AEGQLERVAR IYKHPFYNLY TLDYDVALLE LAGPVRRSRL VRPICLPEPA PRPPDGTRCV ITGWGSVREG GSMARQLQKA AVRLLSEQTC RRFYPVQISS RMLCAGFPQG GVDSCSGDAG GPLACREPSG RWVLTGVTSW GYGCGRPHFP GVYTRVAAVR GWIGQHIQE
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