GTPase ERas (ERAS)

About GTPase ERas

GTPase ERas (ERAS) is a protein from Homo sapiens identified by UniProt accession Q7Z444, 233 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.

Target properties

Protein name	GTPase ERas
UniProt accession	Q7Z444
Gene	ERAS
Organism	Homo sapiens
Length	233 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (20)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.16
gonorrhea · score 0.06
neoplasm · score 0.04
Down syndrome · score 0.03
gastric carcinoma · score 0.02
neuroblastoma · score 0.02
cancer · score 0.01
breast carcinoma · score 0.00
colorectal carcinoma · score 0.00
angiosarcoma · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q7Z444-F1	alphafold	PREDICTED	79.99	—

Amino-acid sequence (233 residues)

MELPTKPGTF DLGLATWSPS FQGETHRAQA RRRDVGRQLP EYKAVVVGAS GVGKSALTIQ LNHQCFVEDH DPTIQDSYWK ELTLDSGDCI LNVLDTAGQA IHRALRDQCL AVCDGVLGVF ALDDPSSLIQ LQQIWATWGP HPAQPLVLVG NKCDLVTTAG DAHAAAAALA HSWGAHFVET SAKTRQGVEE AFSLLVHEIQ RVQEAMAKEP MARSCREKTR HQKATCHCGC SVA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards