Spermatogenesis-associated protein 21 (SPATA21)

About Spermatogenesis-associated protein 21

Spermatogenesis-associated protein 21 (SPATA21) is a protein from Homo sapiens identified by UniProt accession Q7Z572, 469 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.

Target properties

Protein name	Spermatogenesis-associated protein 21
UniProt accession	Q7Z572
Gene	SPATA21
Organism	Homo sapiens
Length	469 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (17)

Diseases linked to this target (Open Targets).

body fat percentage · score 0.06
body mass index · score 0.06
balding measurement · score 0.06
Inguinal hernia · score 0.06
fat body mass · score 0.05
neutrophil percentage of leukocytes · score 0.05
hair shape measurement · score 0.04
pulmonary vascular congestion · score 0.03
cortical surface area measurement · score 0.03
lymphocyte percentage of leukocytes · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q7Z572-F1	alphafold	PREDICTED	59.19	—

Amino-acid sequence (469 residues)

MDNRNTQMYT EEEKTVNPFL PSTPGPKKAK GGGEAVETHP APGPLPPPEV RDIGERREPD RAQQQPQKPA VAAGTQSLGN FRQGFMKCLL EVEKMEASHR RASKARSQTA QKSPRTLTPV PTSAPSLPQT PASVPASGPS WARLPAPGPE PAPMGAPVPT SMPCPVLLGP ALDLGWRRME LLHQSSERTL SYAKARQEPE EQSLQKLYQN REKSEEQLTL KQEEAFRSYF EIFNGPGEVD AQSLKNILLL MGFSVTLAQV EDALMSADVN GDGRVDFKDF LAVMTDTRRF FCSVEQNALS DMAPHNPHTL LFEILSLLVE MLALPEAVLE EITNYYQKKL KEGTCKAQEM EAAVGRLRLQ KLPYNPQQEE SSEVPERKVL SILSRLKQQN YAPNLQSPYA QVPCILLCPQ LDKKMVRRQP SNHYALDQCT PPGLDPDIRS PFFQSGSQGN REHNSDSRKW LSSVPARTH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards