About Polyadenylate-binding protein 2
Polyadenylate-binding protein 2 (PABPN1) is a protein
from Homo sapiens identified by UniProt accession
Q86U42, 306 residues long.
MolForge cross-references it against 0 known binders and
228 disease associations.
Target properties
| Protein name | Polyadenylate-binding protein 2 |
|---|
| UniProt accession | Q86U42 |
|---|
| Gene | PABPN1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 306 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (228)
Diseases linked to this target (Open Targets).
- oculopharyngeal muscular dystrophy · score 0.65
- genetic disorder · score 0.41
- influenza · score 0.37
- lean body mass · score 0.22
- lymphocyte count · score 0.22
- body height · score 0.19
- thyroid gland adenocarcinoma · score 0.18
- appendicular lean mass · score 0.18
- fat body mass · score 0.17
- blood phosphate measurement · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86U42-F1 | alphafold | PREDICTED | 67.85 | — |
Amino-acid sequence (306 residues)
MAAAAAAAAA AGAAGGRGSG PGRRRHLVPG AGGEAGEGAP GGAGDYGNGL ESEELEPEEL LLEPEPEPEP EEEPPRPRAP PGAPGPGPGS GAPGSQEEEE EPGLVEGDPG DGAIEDPELE AIKARVREME EEAEKLKELQ NEVEKQMNMS PPPGNAGPVI MSIEEKMEAD ARSIYVGNVD YGATAEELEA HFHGCGSVNR VTILCDKFSG HPKGFAYIEF SDKESVRTSL ALDESLFRGR QIKVIPKRTN RPGISTTDRG FPRARYRART TNYNSSRSRF YSGFNSRPRG RVYRGRARAT SWYSPY
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