Zinc finger protein 589 (ZNF589)

About Zinc finger protein 589

Zinc finger protein 589 (ZNF589) is a protein from Homo sapiens identified by UniProt accession Q86UQ0, 364 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.

Target properties

Protein name	Zinc finger protein 589
UniProt accession	Q86UQ0
Gene	ZNF589
Organism	Homo sapiens
Length	364 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (38)

Diseases linked to this target (Open Targets).

Diuretic use measurement · score 0.21
body weight · score 0.21
systolic blood pressure · score 0.20
urate measurement · score 0.20
Beta blocking agent use measurement · score 0.20
hepatocyte growth factor-like protein measurement · score 0.14
emotional symptom measurement · score 0.13
coronary artery disease · score 0.11
Agents acting on the renin-angiotensin system use measurement · score 0.10
diastolic blood pressure · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86UQ0-F1	alphafold	PREDICTED	53.96	—

Amino-acid sequence (364 residues)

MWAPREQLLG WTAEALPAKD SAWPWEEKPR YLGPVTFEDV AVLFTEAEWK RLSLEQRNLY KEVMLENLRN LVSLAESKPE VHTCPSCPLA FGSQQFLSQD ELHNHPIPGF HAGNQLHPGN PCPEDQPQSQ HPSDKNHRGA EAEDQRVEGG VRPLFWSTNE RGALVGFSSL FQRPPISSWG GNRILEIQLS PAQNASSEEV DRISKRAETP GFGAVTFGEC ALAFNQKSNL FRQKAVTAEK SSDKRQSQVC RECGRGFSRK SQLIIHQRTH TGEKPYVCGE CGRGFIVESV LRNHLSTHSG EKPYVCSHCG RGFSCKPYLI RHQRTHTREK SFMCTVCGRG FREKSELIKH QRIHTGDKPY VCRD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards