Tripartite motif-containing protein 74 (TRIM74)

About Tripartite motif-containing protein 74

Tripartite motif-containing protein 74 (TRIM74) is a protein from Homo sapiens identified by UniProt accession Q86UV6, 250 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.

Target properties

Protein name	Tripartite motif-containing protein 74
UniProt accession	Q86UV6
Gene	TRIM74
Organism	Homo sapiens
Length	250 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (16)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
BMI-adjusted waist circumference · score 0.12
alkaline phosphatase measurement · score 0.11
body mass index · score 0.08
inflammatory bowel disease 30 · score 0.04
CDH1-related diffuse gastric and lobular breast cancer syndrome · score 0.03
NK-cell enteropathy · score 0.03
gastric carcinoma · score 0.01
hepatocellular carcinoma · score 0.01
neoplasm · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86UV6-F1	alphafold	PREDICTED	88.46	—

Amino-acid sequence (250 residues)

MAWQVSLLEL EDWLQCPICL EVFKESLMLQ CGHSYCKGCL VSLSYHLDTK VRCPMCWQVV DGSSSLPNVS LAWVIEALRL PGDPEPKVCV HHRNPLSLFC EKDQELICGL CGLLGSHQHH PVTPVSTVCS RMKEELAALF SELKQEQKKV DELIAKLVKN RTRIVNESDV FSWVIRREFQ ELRHPVDEEK ARCLEGIGGH TRGLVASLDM QLEQAQGTRE RLAQAECVLE QFGNEDHHEF IWKFHSMASR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards