About Zinc finger and BTB domain-containing protein 46
Zinc finger and BTB domain-containing protein 46 (ZBTB46) is a protein
from Homo sapiens identified by UniProt accession
Q86UZ6, 589 residues long.
MolForge cross-references it against 0 known binders and
189 disease associations.
Target properties
| Protein name | Zinc finger and BTB domain-containing protein 46 |
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| UniProt accession | Q86UZ6 |
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| Gene | ZBTB46 |
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| Organism | Homo sapiens |
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| Length | 589 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (189)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- osteomyelitis · score 0.33
- type 2 diabetes mellitus · score 0.30
- mean corpuscular volume · score 0.30
- birth weight · score 0.28
- diabetes mellitus · score 0.28
- Agents acting on the renin-angiotensin system use measurement · score 0.27
- hypertension · score 0.27
- red blood cell density measurement · score 0.26
- vitamin D measurement · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86UZ6-F1 | alphafold | PREDICTED | 54.84 | — |
Amino-acid sequence (589 residues)
MNNRKEDMEI TSHYRHLLRE LNEQRQHGVL CDVCVVVEGK VFKAHKNVLL GSSRYFKTLY CQVQKTSEQA TVTHLDIVTA QGFKAIIDFM YSAHLALTSR NVIEVMSAAS FLQMTDIVQA CHDFIKAALD ISIKSDASDE LAEFEIGASS SSSTEALISA VMAGRSISPW LARRTSPANS SGDSAIASCH DGGSSYGKED QEPKADGPDD VSSQPLWPGD VGYGPLRIKE EQVSPSQYGG SELPSAKDGA VQNSFSEQSA GDAWQPTGRR KNRKNKETVR HITQQVEDDS RASSPVPSFL PTSGWPFSSR DSNADLSVTE ASSSDSRGER AELYAQVEEG LLGGEASYLG PPLTPEKDDA LHQATAVANL RAALMSKNSL LSLKADVLGD DGSLLFEYLP RGAHSLSLNE FTVIRKKFKC PYCSFSAMHQ CILKRHMRSH TGERPYPCEI CGKKFTRREH MKRHTLVHSK DKKYVCKVCS RVFMSAASVG IRHGSRRHGV CTDCAGRGMA GPLDHGGGGG EGSPEALFPG DGPYLEDPED PRGEAEELGE DDEGLAPEDA LLADDKDEED SPRPRSPPGG PDKDFAWLS
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