Vacuolar protein-sorting-associated protein 36 (VPS36)

About Vacuolar protein-sorting-associated protein 36

Vacuolar protein-sorting-associated protein 36 (VPS36) is a protein from Homo sapiens identified by UniProt accession Q86VN1, 386 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.

Target properties

Protein name	Vacuolar protein-sorting-associated protein 36
UniProt accession	Q86VN1
Gene	VPS36
Organism	Homo sapiens
Length	386 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (52)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
viral disease · score 0.46
age-related macular degeneration · score 0.17
retinitis pigmentosa · score 0.11
disease of genitourinary system · score 0.09
X-linked retinal dysplasia · score 0.08
Progressive cone dystrophy · score 0.07
Familial exudative vitreoretinopathy · score 0.07
severe early-childhood-onset retinal dystrophy · score 0.06
choroidal dystrophy, central areolar, 1 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86VN1-F1	alphafold	PREDICTED	82.77	—

Amino-acid sequence (386 residues)

MDRFVWTSGL LEINETLVIQ QRGVRIYDGE EKIKFDAGTL LLSTHRLIWR DQKNHECCMA ILLSQIVFIE EQAAGIGKSA KIVVHLHPAP PNKEPGPFQS SKNSYIKLSF KEHGQIEFYR RLSEEMTQRR WENMPVSQSL QTNRGPQPGR IRAVGIVGIE RKLEEKRKET DKNISEAFED LSKLMIKAKE MVELSKSIAN KIKDKQGDIT EDETIRFKSY LLSMGIANPV TRETYGSGTQ YHMQLAKQLA GILQVPLEER GGIMSLTEVY CLVNRARGME LLSPEDLVNA CKMLEALKLP LRLRVFDSGV MVIELQSHKE EEMVASALET VSEKGSLTSE EFAKLVGMSV LLAKERLLLA EKMGHLCRDD SVEGLRFYPN LFMTQS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards