Cation channel sperm-associated protein 3 (CATSPER3)

About Cation channel sperm-associated protein 3

Cation channel sperm-associated protein 3 (CATSPER3) is a protein from Homo sapiens identified by UniProt accession Q86XQ3, 398 residues long. MolForge cross-references it against 0 known binders and 134 disease associations.

Target properties

Protein name	Cation channel sperm-associated protein 3
UniProt accession	Q86XQ3
Gene	CATSPER3
Organism	Homo sapiens
Length	398 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (4)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (134)

Diseases linked to this target (Open Targets).

bone density · score 0.41
urate measurement · score 0.39
body height · score 0.33
cutaneous melanoma · score 0.25
lung adenocarcinoma · score 0.23
BMI-adjusted hip circumference · score 0.23
heel bone mineral density · score 0.20
breast adenocarcinoma · score 0.16
squamous cell lung carcinoma · score 0.15
eosinophil count · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86XQ3-F1	alphafold	PREDICTED	79.95	—

Amino-acid sequence (398 residues)

MSQHRHQRHS RVISSSPVDT TSVGFCPTFK KFKRNDDECR AFVKRVIMSR FFKIIMISTV TSNAFFMALW TSYDIRYRLF RLLEFSEIFF VSICTSELSM KVYVDPINYW KNGYNLLDVI IIIVMFLPYA LRQLMGKQFT YLYIADGMQS LRILKLIGYS QGIRTLITAV GQTVYTVASV LLLLFLLMYI FAILGFCLFG SPDNGDHDNW GNLAAAFFTL FSLATVDGWT DLQKQLDNRE FALSRAFTII FILLASFIFL NMFVGVMIMH TEDSIRKFER ELMLEQQEML MGEKQVILQR QQEEISRLMH IQKNADCTSF SELVENFKKT LSHTDPMVLD DFGTSLPFID IYFSTLDYQD TTVHKLQELY YEIVHVLSLM LEDLPQEKPQ SLEKVDEK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards