Thioredoxin domain-containing protein 6 (NME9)

About Thioredoxin domain-containing protein 6

Thioredoxin domain-containing protein 6 (NME9) is a protein from Homo sapiens identified by UniProt accession Q86XW9, 330 residues long. MolForge cross-references it against 0 known binders and 55 disease associations.

Target properties

Protein name	Thioredoxin domain-containing protein 6
UniProt accession	Q86XW9
Gene	NME9
Organism	Homo sapiens
Length	330 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (55)

Diseases linked to this target (Open Targets).

mathematical ability · score 0.41
lysosomal storage disease · score 0.33
Parkinson disease · score 0.33
Alzheimer disease · score 0.33
neurodegenerative disease · score 0.33
multiple sclerosis · score 0.33
cognitive function measurement · score 0.30
coronary artery disease · score 0.10
BMI-adjusted waist-hip ratio · score 0.09
body fat percentage · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86XW9-F1	alphafold	PREDICTED	77.32	—

Amino-acid sequence (330 residues)

MGSRKKEIAL QVNISTQELW EEMLSSKGLT VVDVYQGWCG PCKPVVSLFQ KMRIEVGLDL LHFALAEADR LDVLEKYRGK CEPTFLFYAG GELVAVVRGA NAPLLQKTIL DQLEAEKKVL AEGRERKVIK DEALSDEDEC VSHGKNNGED EDMVSSERTC TLAIIKPDAV AHGKTDEIIM KIQEAGFEIL TNEERTMTEA EVRLFYQHKA GEEAFEKLVH HMCSGPSHLL ILTRTEGFED VVTTWRTVMG PRDPNVARRE QPESLRAQYG TEMPFNAVHG SRDREDADRE LALLFPSLKF SDKDTEAPQG GEAEATAGPT EALCFPEDVD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards