Zinc finger protein 280B (ZNF280B)

About Zinc finger protein 280B

Zinc finger protein 280B (ZNF280B) is a protein from Homo sapiens identified by UniProt accession Q86YH2, 543 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.

Target properties

Protein name	Zinc finger protein 280B
UniProt accession	Q86YH2
Gene	ZNF280B
Organism	Homo sapiens
Length	543 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (14)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.29
Myopia · score 0.24
age at onset · score 0.24
testosterone measurement · score 0.18
exstrophy-epispadias complex · score 0.12
ovarian carcinoma · score 0.01
neoplasm · score 0.01
adrenal cortex carcinoma · score 0.00
goblet cell carcinoma · score 0.00
Vitiligo · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86YH2-F1	alphafold	PREDICTED	59.09	—

Amino-acid sequence (543 residues)

MEQSCEEEKE PEPQKNIQET KQVDDEDAEL IFVGVEHVNE DAELIFVGVT SNSKPVVSNI LNRVTPGSWS RRKKYDHLRK DTARKLQPKS HETVTSEAVT VLPASQLESR STDSPIIIEP LSKPDYRNSS PQVVPNNSSE LPSPLITFTD SLHHPVSTAL SVGGINESPR VSKQLSTFEV NSINPKRAKL RDGIIEGNSS ASFPSDTFHT MNTQQSTPSN NVHTSLSHVQ NGAPFPAAFP KDNIHFKPIN TNLDRANELA KTDILSLTSQ NKTFDPKKEN PIVLLSDFYY GQHKGEGQPE QKTHTTFKCL SCVKVLKNVK FMNHVKHHLE FEKQRNDSWE NHTTCQHCHR QFPTPFQLQC HIENVHTAQE PSTVCKICEL SFETDQVLLQ HMKDHHKPGE MPYVCQVCHY RSSVFADVET HFRTCHENTK NLLCPFCLKI FKTATPYMCH YRGHWGKSAH QCSKCRLQFL TFKEKMEHKT QCHQMFKKPK QLEGLPPETK VTIQVSLEPL QPGSVDVASI TVSTSDSEPS LPRSKSKISK KSH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards