About All trans-polyprenyl-diphosphate synthase PDSS2
All trans-polyprenyl-diphosphate synthase PDSS2 (PDSS2) is a protein
from Homo sapiens identified by UniProt accession
Q86YH6, 399 residues long.
MolForge cross-references it against 0 known binders and
114 disease associations.
Target properties
| Protein name | All trans-polyprenyl-diphosphate synthase PDSS2 |
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| UniProt accession | Q86YH6 |
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| Gene | PDSS2 |
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| Organism | Homo sapiens |
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| Length | 399 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (114)
Diseases linked to this target (Open Targets).
- coenzyme Q10 deficiency, primary, 3 · score 0.75
- neurodegenerative disease · score 0.53
- Leigh syndrome · score 0.51
- coffee consumption · score 0.32
- cups of coffee per day measurement · score 0.32
- nephrotic syndrome · score 0.28
- lifestyle measurement · score 0.25
- brain measurement · score 0.25
- lysosomal storage disease · score 0.20
- genetic disorder · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86YH6-F1 | alphafold | PREDICTED | 80.62 | — |
Amino-acid sequence (399 residues)
MNFRQLLLHL PRYLGASGSP RRLWWSPSLD TISSVGSWRG RSSKSPAHWN QVVSEAEKIV GYPTSFMSLR CLLSDELSNI AMQVRKLVGT QHPLLTTARG LVHDSWNSLQ LRGLVVLLIS KAAGPSSVNT SCQNYDMVSG IYSCQRSLAE ITELIHIALL VHRGIVNLNE LQSSDGPLKD MQFGNKIAIL SGDFLLANAC NGLALLQNTK VVELLASALM DLVQGVYHEN STSKESYITD DIGISTWKEQ TFLSHGALLA KSCQAAMELA KHDAEVQNMA FQYGKHMAMS HKINSDVQPF IKEKTSDSMT FNLNSAPVVL HQEFLGRDLW IKQIGEAQEK GRLDYAKLRE RIKAGKGVTS AIDLCRYHGN KALEALESFP PSEARSALEN IVFAVTRFS
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