Homeobox protein TGIF2LY (TGIF2LY)

About Homeobox protein TGIF2LY

Homeobox protein TGIF2LY (TGIF2LY) is a protein from Homo sapiens identified by UniProt accession Q8IUE0, 185 residues long. MolForge cross-references it against 0 known binders and 3 disease associations.

Target properties

Protein name	Homeobox protein TGIF2LY
UniProt accession	Q8IUE0
Gene	TGIF2LY
Organism	Homo sapiens
Length	185 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (3)

Diseases linked to this target (Open Targets).

male infertility with azoospermia or oligozoospermia due to single gene mutation · score 0.27
Infertility · score 0.01
pulmonary arterial hypertension · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IUE0-F1	alphafold	PREDICTED	68.20	—

Amino-acid sequence (185 residues)

MEAAADGPAE TQSPVEKDSP AKTQSPAQDT SIMSRNNADT GRVLALPEHK KKRKGNLPAE SVKILRDWMY KHRFKAYPSE EEKQMLSEKT NLSLLRISNW FINARRRILP DMLQQRRNDP IIGHKTGKDA HATHLQSTEA SVPAKSGPVV QTMYKACPCG PCQRARCQER SNQIRSRPLA RSSPE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards