C-type lectin domain family 10 member A (CLEC10A)

About C-type lectin domain family 10 member A

C-type lectin domain family 10 member A (CLEC10A) is a protein from Homo sapiens identified by UniProt accession Q8IUN9, 316 residues long. MolForge cross-references it against 0 known binders and 362 disease associations.

Target properties

Protein name	C-type lectin domain family 10 member A
UniProt accession	Q8IUN9
Gene	CLEC10A
Organism	Homo sapiens
Length	316 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (362)

Diseases linked to this target (Open Targets).

sex hormone-binding globulin measurement · score 0.48
blood protein measurement · score 0.27
breast adenocarcinoma · score 0.16
endometrial cancer · score 0.15
interleukin 6 receptor subunit beta measurement · score 0.13
gastric adenocarcinoma · score 0.11
axial length measurement · score 0.10
melanoma · score 0.08
lung adenocarcinoma · score 0.08
Blackfan-Diamond anemia · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IUN9-F1	alphafold	PREDICTED	80.41	—

Amino-acid sequence (316 residues)

MTRTYENFQY LENKVKVQGF KNGPLPLQSL LQRLCSGPCH LLLSLGLGLL LLVIICVVGF QNSKFQRDLV TLRTDFSNFT SNTVAEIQAL TSQGSSLEET IASLKAEVEG FKQERQAGVS ELQEHTTQKA HLGHCPHCPS VCVPVHSEML LRVQQLVQDL KKLTCQVATL NNNASTEGTC CPVNWVEHQD SCYWFSHSGM SWAEAEKYCQ LKNAHLVVIN SREEQNFVQK YLGSAYTWMG LSDPEGAWKW VDGTDYATGF QNWKPGQPDD WQGHGLGGGE DCAHFHPDGR WNDDVCQRPY HWVCEAGLGQ TSQESH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards