About Protein FAM219A
Protein FAM219A (FAM219A) is a protein
from Homo sapiens identified by UniProt accession
Q8IW50, 185 residues long.
MolForge cross-references it against 0 known binders and
21 disease associations.
Target properties
| Protein name | Protein FAM219A |
|---|
| UniProt accession | Q8IW50 |
|---|
| Gene | FAM219A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 185 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (21)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.19
- amelogenesis imperfecta · score 0.04
- tooth agenesis · score 0.04
- Hypoplastic amelogenesis imperfecta · score 0.04
- dentin dysplasia type I · score 0.04
- amelogenesis imperfecta, type ij · score 0.03
- Hypomaturation amelogenesis imperfecta · score 0.03
- dentinogenesis imperfecta · score 0.03
- dentinogenesis imperfecta type 3 · score 0.03
- heart failure · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IW50-F1 | alphafold | PREDICTED | 63.40 | — |
Amino-acid sequence (185 residues)
MMEEIDRFQV PTAHSEMQPL DPAAASISDG DCDAREGESV AMNYKPSPLQ VKLEKQRELA RKGSLKNGSM GSPVNQQPKK NNVMARTRLV VPNKGYSSLD QSPDEKPLVA LDTDSDDDFD MSRYSSSGYS SAEQINQDLN IQLLKDGYRL DEIPDDEDLD LIPPKSVNPT CMCCQATSST ACHIQ
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