About Kelch repeat and BTB domain-containing protein 2
Kelch repeat and BTB domain-containing protein 2 (KBTBD2) is a protein
from Homo sapiens identified by UniProt accession
Q8IY47, 623 residues long.
MolForge cross-references it against 0 known binders and
108 disease associations.
Target properties
| Protein name | Kelch repeat and BTB domain-containing protein 2 |
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| UniProt accession | Q8IY47 |
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| Gene | KBTBD2 |
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| Organism | Homo sapiens |
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| Length | 623 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (108)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.42
- appendicular lean mass · score 0.35
- reticulocyte count · score 0.34
- body height · score 0.33
- mean corpuscular volume · score 0.33
- Red cell distribution width · score 0.33
- mean corpuscular hemoglobin · score 0.33
- mean corpuscular hemoglobin concentration · score 0.31
- chronotype measurement · score 0.30
- creatinine measurement · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IY47-F1 | alphafold | PREDICTED | 86.23 | — |
Amino-acid sequence (623 residues)
MSTQDERQIN TEYAVSLLEQ LKLFYEQQLF TDIVLIVEGT EFPCHKMVLA TCSSYFRAMF MSGLSESKQT HVHLRNVDAA TLQIIITYAY TGNLAMNDST VEQLYETACF LQVEDVLQRC REYLIKKINA ENCVRLLSFA DLFSCEELKQ SAKRMVEHKF TAVYHQDAFM QLSHDLLIDI LSSDNLNVEK EETVREAAML WLEYNTESRS QYLSSVLSQI RIDALSEVTQ RAWFQGLPPN DKSVVVQGLY KSMPKFFKPR LGMTKEEMMI FIEASSENPC SLYSSVCYSP QAEKVYKLCS PPADLHKVGT VVTPDNDIYI AGGQVPLKNT KTNHSKTSKL QTAFRTVNCF YWFDAQQNTW FPKTPMLFVR IKPSLVCCEG YIYAIGGDSV GGELNRRTVE RYDTEKDEWT MVSPLPCAWQ WSAAVVVHDC IYVMTLNLMY CYFPRSDSWV EMAMRQTSRS FASAAAFGDK IFYIGGLHIA TNSGIRLPSG TVDGSSVTVE IYDVNKNEWK MAANIPAKRY SDPCVRAVVI SNSLCVFMRE THLNERAKYV TYQYDLELDR WSLRQHISER VLWDLGRDFR CTVGKLYPSC LEESPWKPPT YLFSTDGTEE FELDGEMVAL PPV
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