About EF-hand calcium-binding domain-containing protein 13
EF-hand calcium-binding domain-containing protein 13 (EFCAB13) is a protein
from Homo sapiens identified by UniProt accession
Q8IY85, 973 residues long.
MolForge cross-references it against 0 known binders and
61 disease associations.
Target properties
| Protein name | EF-hand calcium-binding domain-containing protein 13 |
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| UniProt accession | Q8IY85 |
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| Gene | EFCAB13 |
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| Organism | Homo sapiens |
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| Length | 973 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (61)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.37
- low density lipoprotein cholesterol measurement · score 0.36
- total cholesterol measurement · score 0.32
- Hashimoto's thyroiditis · score 0.28
- neurodegenerative disease · score 0.23
- membrane-bound aminopeptidase P measurement · score 0.21
- brain volume measurement · score 0.20
- blood phosphate measurement · score 0.19
- glucose measurement · score 0.18
- body height · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IY85-F1 | alphafold | PREDICTED | 53.33 | — |
Amino-acid sequence (973 residues)
METKVHLFCQ AEENIDLLDD GSNSFATDLS SGTINHKKYI KFSKTIEKEI SPEIRSLSPE YKKIFETSII FCGEEKSSDF SGEKKVGRKS LQVQQHSKRT EIIPPFLKLS KEKVTRKENS LCKLPNQYSV HKTSSPLCTS SAITREKEML SNLYMTLYDE VTHGYLHSKE LSALHKACKI FSKIRSGKIY VNDLPVILCI LRISISDLEM RQALKTVDID AFQDALKIFC RIKGGRVSTD DVFAVLDSMG IPINREILEE VTKHTYIDSN HMVDIGDIIF TLNELQEQYE DVSITEGSPL NEITSDRKLS SVAGCYLKYK KKNSLSSKLP EPSISKKLNK KSNQYYSKIM ENDDLESKRP KNTWQIRKFL GGVGSSNVGV QEPYSKNGIN FKKHSEKGEI HDSKSKPQSL KSSTSLSKSL DKSDISSIPK LQKPAVRKHS SLQKQVSSTE KTAISTLENF CEAISKLQEN YIAAEELQSI LPSTGINLLD EEFQKIVTDT SRNENGMVEL DDFVNALAKE RSFPECNALP GVIKAIDKIK DKNVDYEDLN TCLQNFGIYL SKPEFKKITE LTEAGETKKV NFKEFIDTMM SNTECFSEKL VLPDAIETLD DLRKETMSVS DLWNTLSSLN SNLKKDEFLA ALELVTVDEG DKVQFEEFAK VVRNMRDAAR LEELQEVVLA ADLLEGDMIA GKNLEDFLRN VGIKSPKEEV EKILQSDFVS EDNMVNIKDC MRALRDTQKF SNYIDFRKEA SNLKLPKVNE IKEAANILSH VDNGKIGIPD LEHALKCLNV NLTEEDFNEA LNCCNVSDNM EVDLKDFLMK MKESPHFQKS KATQILLATT QILQNDLVDV SDLKTLLMDK DLHTANAILT VMLRHVPEHE SGKVSIQEFM TKLSDILTIP KAAGKFYLIC TYCPDLERQA VVYMLKTIQD SIVKAQVSKK QYNMNIKQHK ISLHNFCLNS KANIAKLNPN SKF
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