Ribonuclease SLFN12 (SLFN12)

About Ribonuclease SLFN12

Ribonuclease SLFN12 (SLFN12) is a protein from Homo sapiens identified by UniProt accession Q8IYM2, 578 residues long. MolForge cross-references it against 0 known binders and 267 disease associations.

Target properties

Protein name	Ribonuclease SLFN12
UniProt accession	Q8IYM2
Gene	SLFN12
Organism	Homo sapiens
Length	578 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (267)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.50
neutrophil count · score 0.20
leukocyte count · score 0.17
isolated agammaglobulinemia · score 0.08
platelet count · score 0.08
lung adenocarcinoma · score 0.08
familial atrial fibrillation · score 0.07
Familial short QT syndrome · score 0.07
Romano-Ward syndrome · score 0.07
Brugada syndrome · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IYM2-F1	alphafold	PREDICTED	82.82	—

Amino-acid sequence (578 residues)

MNISVDLETN YAELVLDVGR VTLGENSRKK MKDCKLRKKQ NESVSRAMCA LLNSGGGVIK AEIENEDYSY TKDGIGLDLE NSFSNILLFV PEYLDFMQNG NYFLIFVKSW SLNTSGLRIT TLSSNLYKRD ITSAKVMNAT AALEFLKDMK KTRGRLYLRP ELLAKRPCVD IQEENNMKAL AGVFFDRTEL DRKEKLTFTE STHVEIKNFS TEKLLQRIKE ILPQYVSAFA NTDGGYLFIG LNEDKEIIGF KAEMSDLDDL EREIEKSIRK MPVHHFCMEK KKINYSCKFL GVYDKGSLCG YVCALRVERF CCAVFAKEPD SWHVKDNRVM QLTRKEWIQF MVEAEPKFSS SYEEVISQIN TSLPAPHSWP LLEWQRQRHH CPGLSGRITY TPENLCRKLF LQHEGLKQLI CEEMDSVRKG SLIFSRSWSV DLGLQENHKV LCDALLISQD SPPVLYTFHM VQDEEFKGYS TQTALTLKQK LAKIGGYTKK VCVMTKIFYL SPEGMTSCQY DLRSQVIYPE SYYFTRRKYL LKALFKALKR LKSLRDQFSF AENLYQIIGI DCFQKNDKKM FKSCRRLT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards