About Cilia- and flagella-associated protein 206
Cilia- and flagella-associated protein 206 (CFAP206) is a protein
from Homo sapiens identified by UniProt accession
Q8IYR0, 622 residues long.
MolForge cross-references it against 0 known binders and
180 disease associations.
Target properties
| Protein name | Cilia- and flagella-associated protein 206 |
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| UniProt accession | Q8IYR0 |
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| Gene | CFAP206 |
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| Organism | Homo sapiens |
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| Length | 622 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (180)
Diseases linked to this target (Open Targets).
- Abnormal sperm tail morphology · score 0.33
- monocyte percentage of leukocytes · score 0.22
- early-onset non-syndromic cataract · score 0.10
- azoospermia · score 0.10
- appendicular lean mass · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- Female infertility due to fertilization defect · score 0.09
- entorhinal cortical volume · score 0.09
- Alzheimer disease · score 0.09
- spermatogenic failure 65 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IYR0-F1 | alphafold | PREDICTED | 85.36 | — |
Amino-acid sequence (622 residues)
MPPTQAESVI RSIIREIGQE CAAHGEIVSE TLIAFMVKAV VLDPSNGFNM DRTLMKSDVQ NLVKLCMTRL LDTKNPSLDT IKMQVYFDMN YTNRVEFLEE HHRVLESRLG SVTREITDNR ACAKEELESL YRKIISYVLL RSGLGSPTDI KTVREVTAAL QSVFPQAELG TFLTLSKKDK ERQLKELTMI VTGIRLFNRD CGKGGEGIDD LPAVLHVAIP ATMQHIDYQL ETARSQVYRY TAILEKAAND PLMRAELQPY MLKEALYNIR QYEVFLQIIL SDIITGAQEV EMMTKQLGAH LEQLKMTIKS KIAVPTSQVF PIFIALSTLW TSLQDETIVV GVLSNLFTHI QPFLGAHELY FPERVMQCHL NGATVKTDVC RMKEHMEDRV NVADFRKLEW LFPETTANFD KLLIQYRGFC AYTFAATDGL LLPGNPAIGI LKYKEKYYTF NSKDAAYSFA ENPEHYIDIV REKAKKNTEL IQLLELHQQF ETFIPYSQMR DADKHYIKPI TKCESSTQTN THILPPTIVR SYEWNEWELR RKAIKLANLR QKVTHSVQTD LSHLRRENCS QVYPPKDTST QSMREDSTGV PRPQIYLAGL RGGKSEITDE VKVNLTRDVD ET
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