Synaptonemal complex central element protein 1 (SYCE1)

About Synaptonemal complex central element protein 1

Synaptonemal complex central element protein 1 (SYCE1) is a protein from Homo sapiens identified by UniProt accession Q8N0S2, 351 residues long. MolForge cross-references it against 0 known binders and 165 disease associations.

Target properties

Protein name	Synaptonemal complex central element protein 1
UniProt accession	Q8N0S2
Gene	SYCE1
Organism	Homo sapiens
Length	351 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (165)

Diseases linked to this target (Open Targets).

spermatogenic failure 15 · score 0.46
premature ovarian failure 12 · score 0.45
primary ovarian insufficiency · score 0.44
male infertility with azoospermia or oligozoospermia due to single gene mutation · score 0.39
Primary amenorrhea · score 0.32
head and neck squamous cell carcinoma · score 0.23
breast adenocarcinoma · score 0.22
squamous cell lung carcinoma · score 0.10
gastric adenocarcinoma · score 0.09
azoospermia · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N0S2-F1	alphafold	PREDICTED	77.52	—

Amino-acid sequence (351 residues)

MAGRSLTSKA EPTAGAVDRA EKAGGQDTSS QKIEDLMEMV QKLQKVGSLE PRVEVLINRI NEVQQAKKKA NKDLGEARTI CEALQKELDS LHGEKVHLKE ILSKKQETLR ILRLHCQEKE SEAHRKHTML QECKERISAL NLQIEEEKNK QRQLRLAFEE QLEDLMGQHK DLWDFHMPER LAKEICALDS SKEQLLKEEK LVKATLEDVK HQLCSLCGAE GPSTLDEGLF LRSQEAAATV QLFQEEHRKA EELLAAAAQR HQQLQQKCQQ QQQKRQRLKE ELEKHGMQVP AQAQSTQEEE AGPGDVASPK PLKGERPGAA HQAGPDVLIG QEDTLHPDLS PRGFQEIKEL F

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards