About Sodium-dependent phosphate transport protein 2C
Sodium-dependent phosphate transport protein 2C (SLC34A3) is a protein
from Homo sapiens identified by UniProt accession
Q8N130, 599 residues long.
MolForge cross-references it against 0 known binders and
81 disease associations.
Target properties
| Protein name | Sodium-dependent phosphate transport protein 2C |
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| UniProt accession | Q8N130 |
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| Gene | SLC34A3 |
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| Organism | Homo sapiens |
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| Length | 599 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (81)
Diseases linked to this target (Open Targets).
- hereditary hypophosphatemic rickets with hypercalciuria · score 0.80
- cystatin C measurement · score 0.63
- creatinine measurement · score 0.63
- phosphate measurement · score 0.58
- serum urea measurement · score 0.39
- X-linked hypophosphatemia · score 0.37
- nephrolithiasis · score 0.35
- hypophosphatemic nephrolithiasis/osteoporosis 1 · score 0.35
- urea measurement · score 0.30
- Hypercalciuria · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N130-F1 | alphafold | PREDICTED | 75.76 | — |
Amino-acid sequence (599 residues)
MPSSLPGSQV PHPTLDAVDL VEKTLRNEGT SSSAPVLEEG DTDPWTLPQL KDTSQPWKEL RVAGRLRRVA GSVLKACGLL GSLYFFICSL DVLSSAFQLL GSKVAGDIFK DNVVLSNPVA GLVIGVLVTA LVQSSSTSSS IVVSMVAAKL LTVRVSVPII MGVNVGTSIT STLVSMAQSG DRDEFQRAFS GSAVHGIFNW LTVLVLLPLE SATALLERLS ELALGAASLT PRAQAPDILK VLTKPLTHLI VQLDSDMIMS SATGNATNSS LIKHWCGTTG QPTQENSSCG AFGPCTEKNS TAPADRLPCR HLFAGTELTD LAVGCILLAG SLLVLCGCLV LIVKLLNSVL RGRVAQVVRT VINADFPFPL GWLGGYLAVL AGAGLTFALQ SSSVFTAAVV PLMGVGVISL DRAYPLLLGS NIGTTTTALL AALASPADRM LSALQVALIH FFFNLAGILL WYLVPALRLP IPLARHFGVV TARYRWVAGV YLLLGFLLLP LAAFGLSLAG GMELAAVGGP LVGLVLLVIL VTVLQRRRPA WLPVRLRSWA WLPVWLHSLE PWDRLVTRCC PCNVCSPPKA TTKEAYCYEN PEILASQQL
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