About N-acetylglutamate synthase, mitochondrial
N-acetylglutamate synthase, mitochondrial (NAGS) is a protein
from Homo sapiens identified by UniProt accession
Q8N159, 534 residues long.
MolForge cross-references it against 0 known binders and
77 disease associations.
Target properties
| Protein name | N-acetylglutamate synthase, mitochondrial |
|---|
| UniProt accession | Q8N159 |
|---|
| Gene | NAGS |
|---|
| Organism | Homo sapiens |
|---|
| Length | 534 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (77)
Diseases linked to this target (Open Targets).
- hyperammonemia due to N-acetylglutamate synthase deficiency · score 0.83
- Hyperammonemia due to N-acetylglutamate synthetase deficiency · score 0.81
- genetic disorder · score 0.47
- neurodegenerative disease · score 0.42
- squamous cell lung carcinoma · score 0.13
- apolipoprotein B measurement · score 0.13
- blood phosphate measurement · score 0.11
- Esophageal atresia · score 0.11
- pyloric stenosis · score 0.11
- neoplasm · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N159-F1 | alphafold | PREDICTED | 79.73 | — |
Amino-acid sequence (534 residues)
MATALMAVVL RAAAVAPRLR GRGGTGGARR LSCGARRRAA RGTSPGRRLS TAWSQPQPPP EEYAGADDVS QSPVAEEPSW VPSPRPPVPH ESPEPPSGRS LVQRDIQAFL NQCGASPGEA RHWLTQFQTC HHSADKPFAV IEVDEEVLKC QQGVSSLAFA LAFLQRMDMK PLVVLGLPAP TAPSGCLSFW EAKAQLAKSC KVLVDALRHN AAAAVPFFGG GSVLRAAEPA PHASYGGIVS VETDLLQWCL ESGSIPILCP IGETAARRSV LLDSLEVTAS LAKALRPTKI IFLNNTGGLR DSSHKVLSNV NLPADLDLVC NAEWVSTKER QQMRLIVDVL SRLPHHSSAV ITAASTLLTE LFSNKGSGTL FKNAERMLRV RSLDKLDQGR LVDLVNASFG KKLRDDYLAS LRPRLHSIYV SEGYNAAAIL TMEPVLGGTP YLDKFVVSSS RQGQGSGQML WECLRRDLQT LFWRSRVTNP INPWYFKHSD GSFSNKQWIF FWFGLADIRD SYELVNHAKG LPDSFHKPAS DPGS
Explore N-acetylglutamate synthase, mitochondrial with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets