Sex comb on midleg-like protein 4 (SCML4)

About Sex comb on midleg-like protein 4

Sex comb on midleg-like protein 4 (SCML4) is a protein from Homo sapiens identified by UniProt accession Q8N228, 414 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.

Target properties

Protein name	Sex comb on midleg-like protein 4
UniProt accession	Q8N228
Gene	SCML4
Organism	Homo sapiens
Length	414 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (44)

Diseases linked to this target (Open Targets).

lymphocyte count · score 0.52
lymphocyte percentage of leukocytes · score 0.47
neutrophil percentage of leukocytes · score 0.47
self reported educational attainment · score 0.43
neutrophil-to-lymphocyte ratio · score 0.42
lymphocyte:monocyte ratio · score 0.34
protein measurement · score 0.32
pathological myopia · score 0.32
coronary artery disease · score 0.31
mathematical ability · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N228-F1	alphafold	PREDICTED	68.96	—

Amino-acid sequence (414 residues)

MQSQRIPGRK RGRPSLHSTP MKMAVHNLYS ASAGSLPAVK IPKKRGRKPG YKIKSRVLMT PLALSPPRST PEPDLSSIPQ DAATVPSLAA PQALTVCLYI NKQANAGPYL ERKKVQQLPE HFGPERPSAV LQQAVQACID CAHQQKLVFS LVKQGYGGEM VSVSASFDGK QHLRSLPVVN SIGYVLRFLA KLCRSLLCDD LFSHQPFPRG CSASEKVQEK EEGRMESVKT VTTEEYLVNP VGMNRYSVDT SASTFNHRGS LHPSSSLYCK RQNSGDSHLG GGPAATAGGP RTSPMSSGGP SAPGLRPPAS SPKRNTTSLE GNRCASSPSQ DAQDARRPRS RNPSAWTVED VVWFVKDADP QALGPHVELF RKHEIDGNAL LLLKSDMVMK YLGLKLGPAL KLCYHIDKLK QAKF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards