About DEP domain-containing protein 4
DEP domain-containing protein 4 (DEPDC4) is a protein
from Homo sapiens identified by UniProt accession
Q8N2C3, 294 residues long.
MolForge cross-references it against 0 known binders and
8 disease associations.
Target properties
| Protein name | DEP domain-containing protein 4 |
|---|
| UniProt accession | Q8N2C3 |
|---|
| Gene | DEPDC4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 294 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (8)
Diseases linked to this target (Open Targets).
- adolescent idiopathic scoliosis · score 0.20
- total cholesterol measurement · score 0.17
- heel bone mineral density · score 0.06
- gut microbiome measurement · score 0.03
- urate measurement · score 0.02
- bone density · score 0.02
- atherosclerosis · score 0.00
- neoplasm · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N2C3-F1 | alphafold | PREDICTED | 62.35 | — |
Amino-acid sequence (294 residues)
MVPGEEPARE LMAVLLTPRF RRLVSQNELP GPGLNGPSSR NRRDGFCRKR RTGCSGPFQA TQLWDGIIHS LQAQVEIKRR RHHLQTYKDC FTGSDAVDVV LSHLMQNTCL SSNDISCLKG VHLCQVLMNH KVFEPVGMKK LFKKEKELEF EDSNISLYRF LGNKSSYDCC KRQKDAENEF NETLRPGYEM ISNPLAQEIG EERIEELIHT INGNPALCPN ITVQKPFLRL SKEDVWKEQT LLCLLQLIHL PFLDNILEPP VKTQNLQLNK EEDLVITNTC LDRELIPSLC LPEK
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