Ly6/PLAUR domain-containing protein 1 (LYPD1)

About Ly6/PLAUR domain-containing protein 1

Ly6/PLAUR domain-containing protein 1 (LYPD1) is a protein from Homo sapiens identified by UniProt accession Q8N2G4, 141 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.

Target properties

Protein name	Ly6/PLAUR domain-containing protein 1
UniProt accession	Q8N2G4
Gene	LYPD1
Organism	Homo sapiens
Length	141 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (49)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.28
body weight · score 0.19
body mass index · score 0.17
atopic eczema · score 0.12
hepatocellular carcinoma · score 0.07
systemic scleroderma · score 0.07
drug use measurement · score 0.07
neoplasm · score 0.06
white matter microstructure measurement · score 0.06
non-small cell lung carcinoma · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N2G4-F1	alphafold	PREDICTED	75.96	—

Amino-acid sequence (141 residues)

MWVLGIAATF CGLFLLPGFA LQIQCYQCEE FQLNNDCSSP EFIVNCTVNV QDMCQKEVME QSAGIMYRKS CASSAACLIA SAGYQSFCSP GKLNSVCISC CNTPLCNGPR PKKRGSSASA LRPGLRTTIL FLKLALFSAH C

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards