About Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 (PYROXD2) is a protein
from Homo sapiens identified by UniProt accession
Q8N2H3, 581 residues long.
MolForge cross-references it against 0 known binders and
36 disease associations.
Target properties
| Protein name | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 |
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| UniProt accession | Q8N2H3 |
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| Gene | PYROXD2 |
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| Organism | Homo sapiens |
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| Length | 581 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (36)
Diseases linked to this target (Open Targets).
- urinary metabolite measurement · score 0.50
- serum metabolite measurement · score 0.47
- metabolite measurement · score 0.41
- blood metabolite measurement · score 0.39
- aspartate aminotransferase measurement · score 0.31
- trimethylamine measurement · score 0.31
- asymmetric dimethylarginine measurement · score 0.30
- calcium measurement · score 0.29
- vitamin B6 measurement · score 0.27
- Leigh syndrome · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N2H3-F1 | alphafold | PREDICTED | 91.34 | — |
Amino-acid sequence (581 residues)
MAASGRGLCK AVAASPFPAW RRDNTEARGG LKPEYDAVVI GAGHNGLVAA AYLQRLGVNT AVFERRHVIG GAAVTEEIIP GFKFSRASYL LSLLRPQIYT DLELKKHGLR LHLRNPYSFT PMLEEGAGSK VPRCLLLGTD MAENQKQIAQ FSQKDAQVFP KYEEFMHRLA LAIDPLLDAA PVDMAAFQHG SLLQRMRSLS TLKPLLKAGR ILGAQLPRYY EVLTAPITKV LDQWFESEPL KATLATDAVI GAMTSPHTPG SGYVLLHHVM GGLEGMQGAW GYVQGGMGAL SDAIASSATT HGASIFTEKT VAKVQVNSEG CVQGVVLEDG TEVRSKMVLS NTSPQITFLK LTPQEWLPEE FLERISQLDT RSPVTKINVA VDRLPSFLAA PNAPRGQPLP HHQCSIHLNC EDTLLLHQAF EDAMDGLPSH RPVIELCIPS SLDPTLAPPG CHVVSLFTQY MPYTLAGGKA WDEQERDAYA DRVFDCIEVY APGFKDSVVG RDILTPPDLE RIFGLPGGNI FHCAMSLDQL YFARPVPLHS GYRCPLQGLY LCGSGAHPGG GVMGAAGRNA AHVAFRDLKS M
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