NXPE family member 1 (NXPE1)

About NXPE family member 1

NXPE family member 1 (NXPE1) is a protein from Homo sapiens identified by UniProt accession Q8N323, 547 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.

Target properties

Protein name	NXPE family member 1
UniProt accession	Q8N323
Gene	NXPE1
Organism	Homo sapiens
Length	547 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (20)

Diseases linked to this target (Open Targets).

ulcerative colitis · score 0.42
blood protein measurement · score 0.36
inflammatory bowel disease · score 0.30
protein measurement · score 0.29
inflammatory skin disease · score 0.29
Crohn's disease · score 0.28
psoriasis · score 0.28
ankylosing spondylitis · score 0.28
sclerosing cholangitis · score 0.28
actinic keratosis · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N323-F1	alphafold	PREDICTED	91.46	—

Amino-acid sequence (547 residues)

MSSNTMLQKT LLILISFSVV TWMIFIISQN FTKLWSALNL SISVHYWNNS AKSLFPKTSL IPLKPLTETE LRIKEIIEKL DQQIPPRPFT HVNTTTSATH STATILNPRD TYCRGDQLDI LLEVRDHLGQ RKQYGGDFLR ARMSSPALTA GASGKVMDFN NGTYLVSFTL FWEGQVSLSL LLIHPSEGAS ALWRARNQGY DKIIFKGKFV NGTSHVFTEC GLTLNSNAEL CEYLDDRDQE AFYCMKPQHM PCEALTYMTT RNREVSYLTD KENSLFHRSK VGVEMMKDRK HIDVTNCNKR EKIEETCQVG MKPPVPGGYT LQGKWITTFC NQVQLDTIKI NGCLKGKLIY LLGDSTLRQW IYYFPKVVKT LKFFDLHETG IFKKHLLLDA ERHTQIQWKK HSYPFVTFQL YSLIDHDYIP REIDRLSGDK NTAIVITFGQ HFRPFPIDIF IRRAIGVQKA IERLFLRSPA TKVIIKTENI REMHIETERF GDFHGYIHYL IMKDIFKDLN VGIIDAWDMT IAYGTDTIHP PDHVIGNQIN MFLNYIC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards