About CAP-Gly domain-containing linker protein 4
CAP-Gly domain-containing linker protein 4 (CLIP4) is a protein
from Homo sapiens identified by UniProt accession
Q8N3C7, 705 residues long.
MolForge cross-references it against 0 known binders and
43 disease associations.
Target properties
| Protein name | CAP-Gly domain-containing linker protein 4 |
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| UniProt accession | Q8N3C7 |
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| Gene | CLIP4 |
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| Organism | Homo sapiens |
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| Length | 705 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (43)
Diseases linked to this target (Open Targets).
- squamous cell lung carcinoma · score 0.36
- ovarian cancer · score 0.27
- rhabdomyosarcoma · score 0.26
- neuroblastoma, susceptibility to, 3 · score 0.21
- neuroblastoma · score 0.21
- hereditary neoplastic syndrome · score 0.21
- Inherited cancer-predisposing syndrome · score 0.21
- Pseudo-fractures · score 0.11
- self reported educational attainment · score 0.06
- neurofibrillary tangles measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N3C7-F1 | alphafold | PREDICTED | 71.92 | — |
Amino-acid sequence (705 residues)
MTIEDLPDFP LEGNPLFGRY PFIFSASDTP VIFSISAAPM PSDCEFSFFD PNDASCQEIL FDPKTSVSEL FAILRQWVPQ VQQNIDIIGN EILKRGCNVN DRDGLTDMTL LHYTCKSGAH GIGDVETAVK FATQLIDLGA DISLRSRWTN MNALHYAAYF DVPELIRVIL KTSKPKDVDA TCSDFNFGTA LHIAAYNLCA GAVKCLLEQG ANPAFRNDKG QIPADVVPDP VDMPLEMADA AATAKEIKQM LLDAVPLSCN ISKAMLPNYD HVTGKAMLTS LGLKLGDRVV IAGQKVGTLR FCGTTEFASG QWAGIELDEP EGKNNGSVGK VQYFKCAPKY GIFAPLSKIS KAKGRRKNIT HTPSTKAAVP LIRSQKIDVA HVTSKVNTGL MTSKKDSASE STLSLPPGEE LKTVTEKDVA LLGSVSSCSS TSSLEHRQSY PKKQNAISSN KKTMSKSPSL SSRASAGLNS SATSTANNSR CEGELRLGER VLVVGQRLGT IRFFGTTNFA PGYWYGIELE KPHGKNDGSV GGVQYFSCSP RYGIFAPPSR VQRVTDSLDT LSEISSNKQN HSYPGFRRSF STTSASSQKE INRRNAFSKS KAALRRSWSS TPTAGGIEGS VKLHEGSQVL LTSSNEMGTV RYVGPTDFAS GIWLGLELRS AKGKNDGSVG DKRYFTCKPN HGVLVRPSRV TYRGINGSKL VDENC
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