EH domain-binding protein 1-like protein 1 (EHBP1L1)

About EH domain-binding protein 1-like protein 1

EH domain-binding protein 1-like protein 1 (EHBP1L1) is a protein from Homo sapiens identified by UniProt accession Q8N3D4, 1523 residues long. MolForge cross-references it against 0 known binders and 116 disease associations.

Target properties

Protein name	EH domain-binding protein 1-like protein 1
UniProt accession	Q8N3D4
Gene	EHBP1L1
Organism	Homo sapiens
Length	1523 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (116)

Diseases linked to this target (Open Targets).

Non-immune hydrops fetalis · score 0.52
Red cell distribution width · score 0.39
angina pectoris · score 0.36
coronary artery disease · score 0.35
mean corpuscular hemoglobin concentration · score 0.33
mean corpuscular hemoglobin · score 0.30
mean corpuscular volume · score 0.28
total blood protein measurement · score 0.28
serum albumin measurement · score 0.28
calcium measurement · score 0.25

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N3D4-F1	alphafold	PREDICTED	48.43	—

Amino-acid sequence (1523 residues)

MTSVWKRLQR VGKRAAKFQF VACYHELVLE CTKKWQPDKL VVVWTRRNRR ICSKAHSWQP GIQNPYRGTV VWMVPENVDI SVTLYRDPHV DQYEAKEWTF IIENESKGQR KVLATAEVDL ARHAGPVPVQ VPVRLRLKPK SVKVVQAELS LTLSGVLLRE GRATDDDMQS LASLMSVKPS DVGNLDDFAE SDEDEAHGPG APEARARVPQ PDPSRELKTL CEEEEEGQGR PQQAVASPSN AEDTSPAPVS APAPPARTSR GQGSERANEA GGQVGPEAPR PPETSPEMRS SRQPAQDTAP TPAPRLRKGS DALRPPVPQG EDEVPKASGA PPAGLGSARE TQAQACPQEG TEAHGARLGP SIEDKGSGDP FGRQRLKAEE MDTEDRPEAS GVDTEPRSGG REANTKRSGV RAGEAEESSA VCQVDAEQRS KVRHVDTKGP EATGVMPEAR CRGTPEAPPR GSQGRLGVRT RDEAPSGLSL PPAEPAGHSG QLGDLEGARA AAGQEREGAE VRGGAPGIEG TGLEQGPSVG AISTRPQVSS WQGALLSTAQ GAISRGLGGW EAEAGGSGDL ETETEVVGLE VLGTQEKEVE GSGFPETRTL EIEILGALEK EAARSRVLES EVAGTAQCEG LETQETEVGV IETPGTETEV LGTQKTEAGG SGVLQTRTTI AETEVLVTQE ISGDLGPLKI EDTIQSEMLG TQETEVEASR VPESEAEGTE AKILGTQEIT ARDSGVREIE AEIAESDILV AQEIEVGLLG VLGIETGAAE GAILGTQEIA SRDSGVPGLE ADTTGIQVKE VGGSEVPEIA TGTAETEILG TQEIASRSSG VPGLESEVAG AQETEVGGSG ISGPEAGMAE ARVLMTRKTE IIVPEAEKEE AQTSGVQEAE TRVGSALKYE ALRAPVTQPR VLGSQEAKAE ISGVQGSETQ VLRVQEAEAG VWGMSEGKSG AWGAQEAEMK VLESPENKSG TFKAQEAEAG VLGNEKGKEA EGSLTEASLP EAQVASGAGA GAPRASSPEK AEEDRRLPGS QAPPALVSSS QSLLEWCQEV TTGYRGVRIT NFTTSWRNGL AFCAILHRFY PDKIDYASLD PLNIKQNNKQ AFDGFAALGV SRLLEPADMV LLSVPDKLIV MTYLCQIRAF CTGQELQLVQ LEGGGGAGTY RVGSAQPSPP DDLDAGGLAQ RLRGHGAEGP QEPKEAADRA DGAAPGVASR NAVAGRASKD GGAEAPRESR PAEVPAEGLV NGAGAPGGGG VRLRRPSVNG EPGSVPPPRA HGSFSHVRDA DLLKKRRSRL RNSSSFSMDD PDAGAMGAAA AEGQAPDPSP APGPPTAADS QQPPGGSSPS EEPPPSPGEE AGLQRFQDTS QYVCAELQAL EQEQRQIDGR AAEVEMQLRS LMESGANKLQ EEVLIQEWFT LVNKKNALIR RQDQLQLLME EQDLERRFEL LSRELRAMLA IEDWQKTSAQ QHREQLLLEE LVSLVNQRDE LVRDLDHKER IALEEDERLE RGLEQRRRKL SRQLSRRERC VLS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards