About ADP-ribosylation factor-like protein 14
ADP-ribosylation factor-like protein 14 (ARL14) is a protein
from Homo sapiens identified by UniProt accession
Q8N4G2, 192 residues long.
MolForge cross-references it against 0 known binders and
51 disease associations.
Target properties
| Protein name | ADP-ribosylation factor-like protein 14 |
|---|
| UniProt accession | Q8N4G2 |
|---|
| Gene | ARL14 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 192 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (51)
Diseases linked to this target (Open Targets).
- systolic blood pressure · score 0.32
- malaria · score 0.32
- ulcerative colitis · score 0.24
- mean platelet volume · score 0.24
- protein measurement · score 0.23
- cardiovascular disease · score 0.19
- alcohol use disorder measurement · score 0.13
- non-small cell lung carcinoma · score 0.08
- isolated asymptomatic elevation of creatine phosphokinase · score 0.07
- lung adenocarcinoma · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N4G2-F1 | alphafold | PREDICTED | 92.96 | — |
Amino-acid sequence (192 residues)
MGSLGSKNPQ TKQAQVLLLG LDSAGKSTLL YKLKLAKDIT TIPTIGFNVE MIELERNLSL TVWDVGGQEK MRTVWGCYCE NTDGLVYVVD STDKQRLEES QRQFEHILKN EHIKNVPVVL LANKQDMPGA LTAEDITRMF KVKKLCSDRN WYVQPCCALT GEGLAQGFRK LTGFVKSHMK SRGDTLAFFK QN
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