About Lysoplasmalogenase TMEM86B
Lysoplasmalogenase TMEM86B (TMEM86B) is a protein
from Homo sapiens identified by UniProt accession
Q8N661, 226 residues long.
MolForge cross-references it against 0 known binders and
20 disease associations.
Target properties
| Protein name | Lysoplasmalogenase TMEM86B |
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| UniProt accession | Q8N661 |
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| Gene | TMEM86B |
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| Organism | Homo sapiens |
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| Length | 226 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (20)
Diseases linked to this target (Open Targets).
- serum metabolite measurement · score 0.33
- phosphatidylethanolamine measurement · score 0.33
- systemic lupus erythematosus · score 0.32
- phosphatidylethanolamine ether measurement · score 0.25
- mean reticulocyte volume · score 0.25
- mean corpuscular hemoglobin concentration · score 0.23
- red blood cell density measurement · score 0.18
- mean corpuscular volume · score 0.07
- mean corpuscular hemoglobin · score 0.06
- platelet count · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N661-F1 | alphafold | PREDICTED | 89.58 | — |
Amino-acid sequence (226 residues)
MDAGKAGQTL KTHCSAQRPD VCRWLSPFIL SCCVYFCLWI PEDQLSWFAA LVKCLPVLCL AGFLWVMSPS GGYTQLLQGA LVCSAVGDAC LIWPAAFVPG MAAFATAHLL YVWAFGFSPL QPGLLLLIIL APGPYLSLVL QHLEPDMVLP VAAYGLILMA MLWRGLAQGG SAGWGALLFT LSDGVLAWDT FAQPLPHAHL VIMTTYYAAQ LLITLSALRS PVPKTD
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