Beta-defensin 123 (DEFB123)

About Beta-defensin 123

Beta-defensin 123 (DEFB123) is a protein from Homo sapiens identified by UniProt accession Q8N688, 67 residues long. MolForge cross-references it against 0 known binders and 9 disease associations.

Target properties

Protein name	Beta-defensin 123
UniProt accession	Q8N688
Gene	DEFB123
Organism	Homo sapiens
Length	67 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (9)

Diseases linked to this target (Open Targets).

lung adenocarcinoma · score 0.24
cutaneous melanoma · score 0.23
squamous cell lung carcinoma · score 0.17
alkaline phosphatase measurement · score 0.15
head and neck squamous cell carcinoma · score 0.15
gastric carcinoma · score 0.03
monocyte count · score 0.02
adolescent idiopathic scoliosis · score 0.02
Sepsis · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N688-F1	alphafold	PREDICTED	83.53	—

Amino-acid sequence (67 residues)

MKLLLLTLTV LLLLSQLTPG GTQRCWNLYG KCRYRCSKKE RVYVYCINNK MCCVKPKYQP KERWWPF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards