About Germinal center-associated signaling and motility protein
Germinal center-associated signaling and motility protein (GCSAM) is a protein
from Homo sapiens identified by UniProt accession
Q8N6F7, 178 residues long.
MolForge cross-references it against 0 known binders and
41 disease associations.
Target properties
| Protein name | Germinal center-associated signaling and motility protein |
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| UniProt accession | Q8N6F7 |
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| Gene | GCSAM |
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| Organism | Homo sapiens |
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| Length | 178 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (41)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.37
- eosinophil percentage of leukocytes · score 0.25
- neutrophil percentage of granulocytes · score 0.22
- eosinophil percentage of granulocytes · score 0.20
- sum of eosinophil and basophil counts · score 0.19
- neurodegenerative disease · score 0.16
- glucuronate measurement · score 0.16
- hip circumference · score 0.09
- diffuse large B-cell lymphoma · score 0.05
- neoplasm · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N6F7-F1 | alphafold | PREDICTED | 56.91 | — |
Amino-acid sequence (178 residues)
MGNSLLRENR RQQNTQEMPW NVRMQSPKQR TSRCWDHHIA EGCFCLPWKK ILIFEKRQDS QNENERMSST PIQDNVDQTY SEELCYTLIN HRVLCTRPSG NSAEEYYENV PCKAERPRES LGGTETEYSL LHMPSTDPRH ARSPEDEYEL LMPHRISSHF LQQPRPLMAP SETQFSHL
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