Leucine-rich repeat-containing protein 52 (LRRC52)

About Leucine-rich repeat-containing protein 52

Leucine-rich repeat-containing protein 52 (LRRC52) is a protein from Homo sapiens identified by UniProt accession Q8N7C0, 313 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.

Target properties

Protein name	Leucine-rich repeat-containing protein 52
UniProt accession	Q8N7C0
Gene	LRRC52
Organism	Homo sapiens
Length	313 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (34)

Diseases linked to this target (Open Targets).

body height · score 0.35
adolescent idiopathic scoliosis · score 0.27
granulocyte count · score 0.10
azoospermia · score 0.06
male infertility with teratozoospermia due to single gene mutation · score 0.06
Male infertility with spermatogenesis disorder due to single gene mutation · score 0.05
spermatogenic failure 3 · score 0.05
spermatogenic failure 55 · score 0.05
spermatogenic failure 7 · score 0.05
spermatogenic failure 29 · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N7C0-F1	alphafold	PREDICTED	86.96	—

Amino-acid sequence (313 residues)

MSLASGPGPG WLLFSFGMGL VSGSKCPNNC LCQAQEVICT GKQLTEYPLD IPLNTRRLFL NENRITSLPA MHLGLLSDLV YLDCQNNRIR EVMDYTFIGV FKLIYLDLSS NNLTSISPFT FSVLSNLVQL NIANNPHLLS LHKFTFANTT SLRYLDLRNT GLQTLDSAAL YHLTTLETLF LSGNPWKCNC SFLDFAIFLI VFHMDPSDDL NATCVEPTEL TGWPITRVGN PLRYMCITHL DHKDYIFLLL IGFCIFAAGT VAAWLTGVCA VLYQNTRHKS SEEDEDEAGT RVEVSRRIFQ TQTSSVQEFP QLI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards