Testis-specific Y-encoded-like protein 6 (TSPYL6)

About Testis-specific Y-encoded-like protein 6

Testis-specific Y-encoded-like protein 6 (TSPYL6) is a protein from Homo sapiens identified by UniProt accession Q8N831, 410 residues long. MolForge cross-references it against 0 known binders and 35 disease associations.

Target properties

Protein name	Testis-specific Y-encoded-like protein 6
UniProt accession	Q8N831
Gene	TSPYL6
Organism	Homo sapiens
Length	410 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (35)

Diseases linked to this target (Open Targets).

telomere length · score 0.26
lean body mass · score 0.20
base metabolic rate measurement · score 0.18
whole body water mass · score 0.17
fat body mass · score 0.17
appendicular lean mass · score 0.14
body height · score 0.10
blood protein measurement · score 0.08
circadian rhythm · score 0.07
neck injury · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N831-F1	alphafold	PREDICTED	63.43	—

Amino-acid sequence (410 residues)

MSLPESPHSP ATLDYALEDP HQGQRSREKS KATEVMADMF DGRLEPIVFP PPRLPEEGVA PQDPADGGHT FHILVDAGRS HGAIKAGQEV TPPPAEGLEA ASASLTTDGS LKNGFPGEET HGLGGEKALE TCGAGRSESE VIAEGKAEDV KPEECAMFSA PVDEKPGGEE MDVAEENRAI DEVNREAGPG PGPGPLNVGL HLNPLESIQL ELDSVNAEAD RALLQVERRF GQIHEYYLEQ RNDIIRNIPG FWVTAFRHHP QLSAMIRGQD AEMLSYLTNL EVKELRHPRT GCKFKFFFQR NPYFRNKLIV KVYEVRSFGQ VVSFSTLIMW RRGHGPQSFI HRNRHVICSF FTWFSDHSLP ESDRIAQIIK EDLWSNPLQY YLLGEDAHRA RRRLVREPVE IPRPFGFQCG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards