FERM domain-containing protein 1 (FRMD1)

About FERM domain-containing protein 1

FERM domain-containing protein 1 (FRMD1) is a protein from Homo sapiens identified by UniProt accession Q8N878, 549 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.

Target properties

Protein name	FERM domain-containing protein 1
UniProt accession	Q8N878
Gene	FRMD1
Organism	Homo sapiens
Length	549 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (33)

Diseases linked to this target (Open Targets).

atrial fibrillation · score 0.33
atrial flutter · score 0.33
erythrocyte count · score 0.32
multiple sclerosis · score 0.29
neurodegenerative disease · score 0.29
lysosomal storage disease · score 0.29
Parkinson disease · score 0.29
Alzheimer disease · score 0.29
bone quantitative ultrasound measurement · score 0.12
myopathy · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N878-F1	alphafold	PREDICTED	65.44	—

Amino-acid sequence (549 residues)

MAVPPRGRGI DPARTNPDTF PPSGARCMEP SPERPACSQQ EPTLGMDAMA SEHRDVLVLL PSREQLRLAV GVKATGRELF QQVCNVASIR DAQFFGLCVV RNNEYIFMDL EQKLSKYFSK DWKKERNEGN EKPRAPFVAF LRVQHYVENG RVISDHRARH LYYCHLKERV LRSQCAHREE AYFLLAACAL QADLGEHRES AHAGRYFEPH SYFPQWIITK RGIDYILRHM PTLHRERQGL SPKEAMLCFI QEACRLEDVP VHFFRLHKDK KEGRPTVILG LALRGVHIYQ GKKLEIQLDG LPAAQKLVYY TGCTWRSRHL LHLLRASHQL HLRVRPTLQQ LRQREEAEEK QHYRESYISD ELELDLASRS FPGSGVSSQH CPHCLSRHSA DSHGSSYTSG IKANSWLRES REMSVDVPLE VHGLHEKEPS SSPRTSRSHP STRGDSQATR QEPCTQVRTR GQSAEAVHQI QEMTAGVSEE QHSHGLDDMQ LHQLALHPAP TSLSHTFHRA LDCRLAGPCE TRATLPSKRS SNCLALDLFG EAPPQEFVV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards