About Cyclic GMP-AMP synthase
Cyclic GMP-AMP synthase (CGAS) is a protein
from Homo sapiens identified by UniProt accession
Q8N884, 522 residues long.
MolForge cross-references it against 0 known binders and
468 disease associations.
Target properties
| Protein name | Cyclic GMP-AMP synthase |
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| UniProt accession | Q8N884 |
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| Gene | CGAS |
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| Organism | Homo sapiens |
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| Length | 522 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (468)
Diseases linked to this target (Open Targets).
- mean corpuscular hemoglobin concentration · score 0.19
- neoplasm · score 0.12
- cancer · score 0.11
- hepatocellular carcinoma · score 0.10
- Rheumatoid arthritis · score 0.10
- non-small cell lung carcinoma · score 0.09
- infection · score 0.09
- infect · score 0.09
- head and neck squamous cell carcinoma · score 0.08
- Huntington disease · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N884-F1 | alphafold | PREDICTED | 76.77 | — |
Amino-acid sequence (522 residues)
MQPWHGKAMQ RASEAGATAP KASARNARGA PMDPTESPAA PEAALPKAGK FGPARKSGSR QKKSAPDTQE RPPVRATGAR AKKAPQRAQD TQPSDATSAP GAEGLEPPAA REPALSRAGS CRQRGARCST KPRPPPGPWD VPSPGLPVSA PILVRRDAAP GASKLRAVLE KLKLSRDDIS TAAGMVKGVV DHLLLRLKCD SAFRGVGLLN TGSYYEHVKI SAPNEFDVMF KLEVPRIQLE EYSNTRAYYF VKFKRNPKEN PLSQFLEGEI LSASKMLSKF RKIIKEEIND IKDTDVIMKR KRGGSPAVTL LISEKISVDI TLALESKSSW PASTQEGLRI QNWLSAKVRK QLRLKPFYLV PKHAKEGNGF QEETWRLSFS HIEKEILNNH GKSKTCCENK EEKCCRKDCL KLMKYLLEQL KERFKDKKHL DKFSSYHVKT AFFHVCTQNP QDSQWDRKDL GLCFDNCVTY FLQCLRTEKL ENYFIPEFNL FSSNLIDKRS KEFLTKQIEY ERNNEFPVFD EF
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