Leucine-rich single-pass membrane protein 1 (LSMEM1)

About Leucine-rich single-pass membrane protein 1

Leucine-rich single-pass membrane protein 1 (LSMEM1) is a protein from Homo sapiens identified by UniProt accession Q8N8F7, 131 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.

Target properties

Protein name	Leucine-rich single-pass membrane protein 1
UniProt accession	Q8N8F7
Gene	LSMEM1
Organism	Homo sapiens
Length	131 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (10)

Diseases linked to this target (Open Targets).

electrocardiography · score 0.43
monocyte count · score 0.15
gut microbiome measurement · score 0.12
monocyte percentage of leukocytes · score 0.11
pleural disorder · score 0.06
mathematical ability · score 0.03
inflammation · score 0.00
psoriasis · score 0.00
Bartsocas-Papas syndrome 1 · score 0.00
cardiovascular disease · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N8F7-F1	alphafold	PREDICTED	67.87	—

Amino-acid sequence (131 residues)

MTHSSQDTGS CGIQEDGKLY VVDSINDLNK LNLCPAGSQH LFPLEDKIPV LGTNSGNGSR SLFFVGLLIV LIVSLALVFF VIFLIVQTGN KMDDVSRRLT AEGKDIDDLK RINNMIVKRL NQLNQLDSEQ N

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards