Ankyrin repeat domain-containing protein 42 (ANKRD42)

About Ankyrin repeat domain-containing protein 42

Ankyrin repeat domain-containing protein 42 (ANKRD42) is a protein from Homo sapiens identified by UniProt accession Q8N9B4, 389 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.

Target properties

Protein name	Ankyrin repeat domain-containing protein 42
UniProt accession	Q8N9B4
Gene	ANKRD42
Organism	Homo sapiens
Length	389 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (14)

Diseases linked to this target (Open Targets).

chronotype measurement · score 0.06
brain volume measurement · score 0.02
pulmonary fibrosis · score 0.01
neoplasm · score 0.01
immature platelet fraction · score 0.00
squamous cell carcinoma · score 0.00
acute myocardial infarction · score 0.00
myocardial infarction · score 0.00
Myocardial Ischemia · score 0.00
diabetes mellitus · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N9B4-F1	alphafold	PREDICTED	77.48	—

Amino-acid sequence (389 residues)

MPGVANSGPS TSSRETANPC SRKKVHFGSI HDAVRAGDVK QLSEIVCLHW LLWHGADITH VTTRGWTASH IAAIRGQDAC VQALIMNGAN LTAQDDRGCT PLHLAATHGH SFTLQIMLRS GVDPSVTDKR EWRPVHYAAF HGRLGCLQLL VKWGCSIEDV DYNGNLPVHL AAMEGHLHCF KFLVSRMSSA TQVLKAFNDN GENVLDLAQR FFKQNILQFI QGAEYEGKDL EDQETLAFPG HVAAFKGDLG MLKKLVEDGV ININERADNG STPMHKAAGQ GHIECLQWLI KMGADSNITN KAGERPSDVA KRFAHLAAVK LLEELQKYDI DDENEIDEND VKYFIRHGVE GSTDAKDDLC LSDLDKTDAR RPSKNCRASW SMNDYVEKN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards