Ras-GEF domain-containing family member 1A (RASGEF1A)

About Ras-GEF domain-containing family member 1A

Ras-GEF domain-containing family member 1A (RASGEF1A) is a protein from Homo sapiens identified by UniProt accession Q8N9B8, 481 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.

Target properties

Protein name	Ras-GEF domain-containing family member 1A
UniProt accession	Q8N9B8
Gene	RASGEF1A
Organism	Homo sapiens
Length	481 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (47)

Diseases linked to this target (Open Targets).

total blood protein measurement · score 0.34
insomnia · score 0.32
breast adenocarcinoma · score 0.29
appendicular lean mass · score 0.28
asthma · score 0.27
brain measurement · score 0.24
cortical surface area measurement · score 0.19
Hirschsprung disease · score 0.09
blood protein measurement · score 0.07
attention deficit-hyperactivity disorder 8 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N9B8-F1	alphafold	PREDICTED	84.76	—

Amino-acid sequence (481 residues)

MPQTSVVFSS ILGPSCSGQV QPGMGERGGG AGGGSGDLIF QDGHLISGSL EALMEHLVPT VDYYPDRTYI FTFLLSSRVF MPPHDLLARV GQICVEQKQQ LEAGPEKAKL KSFSAKIVQL LKEWTEAFPY DFQDEKAMAE LKAITHRVTQ CDEENGTVKK AIAQMTQSLL LSLAARSQLQ ELREKLRPPA VDKGPILKTK PPAAQKDILG VCCDPLVLAQ QLTHIELDRV SSIYPEDLMQ IVSHMDSLDN HRCRGDLTKT YSLEAYDNWF NCLSMLVATE VCRVVKKKHR TRMLEFFIDV ARECFNIGNF NSMMAIISGM NLSPVARLKK TWSKVKTAKF DVLEHHMDPS SNFCNYRTAL QGATQRSQMA NSSREKIVIP VFNLFVKDIY FLHKIHTNHL PNGHINFKKF WEISRQIHEF MTWTQVECPF EKDKKIQSYL LTAPIYSEEA LFVASFESEG PENHMEKDSW KTLRTTLLNR A

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards