About Poly(A)-specific ribonuclease PNLDC1
Poly(A)-specific ribonuclease PNLDC1 (PNLDC1) is a protein
from Homo sapiens identified by UniProt accession
Q8NA58, 520 residues long.
MolForge cross-references it against 0 known binders and
148 disease associations.
Target properties
| Protein name | Poly(A)-specific ribonuclease PNLDC1 |
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| UniProt accession | Q8NA58 |
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| Gene | PNLDC1 |
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| Organism | Homo sapiens |
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| Length | 520 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (148)
Diseases linked to this target (Open Targets).
- male infertility with azoospermia or oligozoospermia due to single gene mutation · score 0.56
- azoospermia · score 0.37
- male infertility · score 0.30
- lipoprotein A measurement · score 0.21
- partial chromosome Y deletion · score 0.08
- spermatogenic failures 50 · score 0.07
- spermatogenic failure, X-linked, 2 · score 0.07
- spermatogenic failure 25 · score 0.07
- Fuchs endothelial corneal dystrophy · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NA58-F1 | alphafold | PREDICTED | 89.99 | — |
Amino-acid sequence (520 residues)
MFCTRGLLFF AFLAGLDIEF TGLRSNLSGP QQISLFDLPS EWYLKTRQSV QQFTVCQIGL SVFSAIEGEA NKYIAHSCNF YLFPTTFGIL DSEFSFQASS VQFLNQYGFN YNKFLKNGIP YMNEEQEKKI RHDILTGNWR VRSSPDKDQI KVVIDEVTRW LELAKEGDWM TLPGITGFQA FEVQLVLRQA LPNIWTVLKD EGVVVKKVSK QHRWYLQNTS CDRESCWKEN ILLSARGFSV FFQMLVKAQK PLVGHNMMMD LLHLHEKFFR PLPESYDQFK QNIHSLFPVL IDTKSVTKDI WKEMNFPRVS NLSEVYEVLN SDLNPTKNSG PEIVHASRCE KYVETKCPHE AAYDAFLCGS VLLKVAHLLL QKIYHIDPVP ESSFPQYLDV LAPYVNQVNL IRAGVPKINF SGPDYPSIRP PILILSVKRW PGVSEQQVYH KFQNLCKFDV RRLTRSQFLL LTNKFKDARN ILKEYRDHPT LCISLYRYWR HSPNVNCLLQ VCGIVTAWAL LAFILGRSGT
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