Protein chibby homolog 2 (CBY2)

About Protein chibby homolog 2

Protein chibby homolog 2 (CBY2) is a protein from Homo sapiens identified by UniProt accession Q8NA61, 448 residues long. MolForge cross-references it against 0 known binders and 9 disease associations.

Target properties

Protein name	Protein chibby homolog 2
UniProt accession	Q8NA61
Gene	CBY2
Organism	Homo sapiens
Length	448 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (9)

Diseases linked to this target (Open Targets).

nasopharyngeal neoplasm · score 0.29
gut microbiome measurement · score 0.21
body height · score 0.18
non-small cell lung carcinoma · score 0.03
neoplasm · score 0.00
colorectal adenocarcinoma · score 0.00
Azoospermia · score 0.00
colorectal neoplasm · score 0.00
male infertility · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NA61-F1	alphafold	PREDICTED	62.74	—

Amino-acid sequence (448 residues)

MSPLECSECF GDQLLHRTYT WQLTLHSRPN YTRKRDTRSE SLEIPISVVL PQRGTAEPFP RLHNLYSTPR CAQQAALPRL SRRMASQHSY PLNRFSSVPL DPMERPMSQA DLELDYNPPR VQLSDEMFVF QDGRWVNENC RLQSPYFSPS ASFHHKLHHK RLAKECMLQE ENKSLREENK ALREENRMLS KENKILQVFW EEHKASLGRE ESRAPSPLLH KDSASLEVVK KDHVALQVPR GKEDSTLQLL REENRALQQL LEQKQAYWAQ AEDTAAPAEE SKPAPSPHEE PCSPGLLQDQ GSGLSSRFEE PKGPPARQED SKELRALRKM VSNMSGPSGE EEAKVGPGLP DGCQPLQLLR EMRQALQALL KENRLLQEEN RTLQVLRAEH RGFQEENKAL WENNKLKLQQ KLVIDTVTEV TARMEMLIEE LYAFMPARSQ DPKKPSRV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards