About Kinetochore protein Spc24
Kinetochore protein Spc24 (SPC24) is a protein
from Homo sapiens identified by UniProt accession
Q8NBT2, 197 residues long.
MolForge cross-references it against 0 known binders and
72 disease associations.
Target properties
| Protein name | Kinetochore protein Spc24 |
|---|
| UniProt accession | Q8NBT2 |
|---|
| Gene | SPC24 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 197 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (72)
Diseases linked to this target (Open Targets).
- hypercholesterolemia, familial, 1 · score 0.51
- low density lipoprotein cholesterol measurement · score 0.33
- total cholesterol measurement · score 0.31
- coronary artery disease · score 0.29
- angina pectoris · score 0.25
- apolipoprotein A 1 measurement · score 0.24
- myocardial infarction · score 0.21
- HMG CoA reductase inhibitor use measurement · score 0.21
- high density lipoprotein cholesterol measurement · score 0.19
- reticulocyte measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NBT2-F1 | alphafold | PREDICTED | 91.38 | — |
Amino-acid sequence (197 residues)
MAAFRDIEEV SQGLLSLLGA NRAEAQQRRL LGRHEQVVER LLETQDGAEK QLREILTMEK EVAQSLLNAK EQVHQGGVEL QQLEAGLQEA GEEDTRLKAS LLQLTRELEE LKEIEADLER QEKEVDEDTT VTIPSAVYVA QLYHQVSKIE WDYECEPGMV KGIHHGPSVA QPIHLDSTQL SRKFISDYLW SLVDTEW
Explore Kinetochore protein Spc24 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets