BTB/POZ domain-containing protein KCTD6 (KCTD6)

About BTB/POZ domain-containing protein KCTD6

BTB/POZ domain-containing protein KCTD6 (KCTD6) is a protein from Homo sapiens identified by UniProt accession Q8NC69, 237 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.

Target properties

Protein name	BTB/POZ domain-containing protein KCTD6
UniProt accession	Q8NC69
Gene	KCTD6
Organism	Homo sapiens
Length	237 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (21)

Diseases linked to this target (Open Targets).

systemic lupus erythematosus · score 0.23
cortical thickness · score 0.12
serum alanine aminotransferase measurement · score 0.10
aspartate aminotransferase measurement · score 0.10
systemic scleroderma · score 0.05
1,5 anhydroglucitol measurement · score 0.04
body height · score 0.04
head and neck squamous cell carcinoma · score 0.02
BMI-adjusted waist circumference · score 0.02
hematocrit · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NC69-F1	alphafold	PREDICTED	87.23	—

Amino-acid sequence (237 residues)

MDNGDWGYMM TDPVTLNVGG HLYTTSLTTL TRYPDSMLGA MFGGDFPTAR DPQGNYFIDR DGPLFRYVLN FLRTSELTLP LDFKEFDLLR KEADFYQIEP LIQCLNDPKP LYPMDTFEEV VELSSTRKLS KYSNPVAVII TQLTITTKVH SLLEGISNYF TKWNKHMMDT RDCQVSFTFG PCDYHQEVSL RVHLMEYITK QGFTIRNTRV HHMSERANEN TVEHNWTFCR LARKTDD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards