About RING finger protein 214
RING finger protein 214 (RNF214) is a protein
from Homo sapiens identified by UniProt accession
Q8ND24, 703 residues long.
MolForge cross-references it against 0 known binders and
29 disease associations.
Target properties
| Protein name | RING finger protein 214 |
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| UniProt accession | Q8ND24 |
|---|
| Gene | RNF214 |
|---|
| Organism | Homo sapiens |
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| Length | 703 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (29)
Diseases linked to this target (Open Targets).
- plasma beta-amyloid 1-40 measurement · score 0.19
- triglyceride measurement · score 0.15
- proprotein convertase subtilisin/kexin type 7 measurement · score 0.15
- mean platelet volume · score 0.12
- hepatocellular carcinoma · score 0.08
- hemoglobin D disease · score 0.04
- pseudohypoparathyroidism type 2 · score 0.04
- hypoparathyroidism, familial isolated, 2 · score 0.04
- hemoglobin E-beta-thalassemia syndrome · score 0.04
- appendicular lean mass · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8ND24-F1 | alphafold | PREDICTED | 64.17 | — |
Amino-acid sequence (703 residues)
MAASEVAGVV ANAPSPPESS SLCASKSDEG LPDGLSTKDS AQKQKNSPLL SVSSQTITKE NNRNVHLEHS EQNPGSSAGD TSAAHQVVLG ENLIATALCL SGSGSQSDLK DVASTAGEEG DTSLRESLHP VTRSLKAGCH TKQLASRNCS EEKSPQTSIL KEGNRDTSLD FRPVVSPANG VEGVRVDQDD DQDSSSLKLS QNIAVQTDFK TADSEVNTDQ DIEKNLDKMM TERTLLKERY QEVLDKQRQV ENQLQVQLKQ LQQRREEEMK NHQEILKAIQ DVTIKREETK KKIEKEKKEF LQKEQDLKAE IEKLCEKGRR EVWEMELDRL KNQDGEINRN IMEETERAWK AEILSLESRK ELLVLKLEEA EKEAELHLTY LKSTPPTLET VRSKQEWETR LNGVRIMKKN VRDQFNSHIQ LVRNGAKLSS LPQIPTPTLP PPPSETDFML QVFQPSPSLA PRMPFSIGQV TMPMVMPSAD PRSLSFPILN PALSQPSQPS SPLPGSHGRN SPGLGSLVSP HGPHMPPAAS IPPPPGLGGV KASAETPRPQ PVDKLEKILE KLLTRFPQCN KAQMTNILQQ IKTARTTMAG LTMEELIQLV AARLAEHERV AASTQPLGRI RALFPAPLAQ ISTPMFLPSA QVSYPGRSSH APATCKLCLM CQKLVQPSEL HPMACTHVLH KECIKFWAQT NTNDTCPFCP TLK
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